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KMID : 0043320060290070563
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Archives of Pharmacal Research
2006 Volume.29 No. 7 p.563 ~ p.565
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A Convergent Synthesis of an Anti-Helicobacter Pylori Agent, Dehydrodiconiferyl Alcohol
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Hu Kun
Jeong Jin-Hyun
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Abstract
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Potential anti-Helicobacter pylori agent dehydrodiconiferyl alcohol was synthesized in 44% overall yield, starting from vanillin which could be commercially available. Carbon extension of vanillin followed by the Horner-Wadsworth-Emmons reaction, a biomolecular radical coupling reaction and DIBAL-H reduction gave dehydrodiconiferyl alcohol.
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KEYWORD
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Anti-Helicobacter pylori agent, Dehydrodiconiferyl alcoho, Vanillin, Horner-Wadsworth-Emmons reaction, Radical coupling reaction
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